MCD

Our sortium will focus on the integration of four novel trol components in a low-tech (no power source, no need for CO2) and cheap mosquito tamination device (MCD) that will a) lure malaria mosquitoes to an attractive point source, b) infect them there with a fungus as a slow-killing agent, and c) expose them to a juvenile hormone analogue with which they will taminate their breeding sites and kill mosquito larvae. This is unique because it will be the first vector trol tool that targets both adult and larval mosquito stages simultaneously with environment-friendly trol agents. We foresee the use of MCDs mostly in the outdoor environment where they will lure, infect, and taminate host-seeking and resting females. Together with the excito-repellent properties of insecticides used for indoor spraying and bednet impregnation, and possibly spatial repellents, MCDs will serve within a push-pull framework. We aim to develop a low-cost MCD that operates uninterrupted and without maintenance for prolonged periods of. MCDs will be highly useful in areas where insecticide-resistance is hampering the effectiveness of current vector trol tools and where behavioural adaptation of mosquito populations has shifted towards outdoor resting and biting. Our goal is to have several prototypes of MCDs in an advanced stage of development and ready for industrial production at the end of this 3-year project. By then, extensive (semi-)field testing in Tanzania and various other countries will have been completed. This proposal brings together a unique mix of business-oriented and academic/institutional partners with a broad range of expertises in fungus and mosquito biology, mosquito behaviour, trapping technology, materials sciences and entrepreneurial interests. We will synergise our abilities to make substantial progress to achieve our goal: to add a novel, effective, and eomic alternative to the limited vector trol toolbox available to combat malaria.