Allosteric effects induced in 14-3-3 targets

14-3-3 proteins, found in all eukaryotic cells, are known to be important in cell-cycle regulation, apoptosis, and regulation of gene expression. They are also associated with oncogenic and neurodegenerative amyloid diseases. 14-3-3 proteins are active as homo- or heterodimers and bind more than 300 diverse target phosphoproteins, thereby forcing conformational changes or/and stabilizing active conformations in their target proteins.

Short name and number: 
14_3_3 (235902)
Name of US Partner: 
UNIVERSITY OF PITTSBURGH
Contact: 

Masarykova univerzita (CZ) / SKLENAR Vladimir

Participating Countries: 
United States
Area: 

No theme specific

Category: 

FP7 Project with U.S. partner